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Genetic Determinants of Serum Testosterone Concentrations in Men - 0 views

journals.plos.org/...article epigenetics low T low Testosterone SNP single nucleotide polymorphisms testosterone
shared by Nathan Goodyear on 06 Sep 17 - No Cached
  • Nathan Goodyear on 06 Sep 17
     
    SNP as significant contributor to low Testosterone in men via SHBG polymorphism and reduces the free Testosterone.
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Genetic Analysis of 16 NMR-Lipoprotein Fractions in H... [Lipids. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23192668 SNPs single nucleotide polymorphisms genes genetics lipid metabolism metabolism weight overweight obesity
shared by Nathan Goodyear on 24 Jan 13 - No Cached
  • Nathan Goodyear on 24 Jan 13
     
    genetic SNPs play a role in lipid/fat metabolism. A person's weight problem may be, in part, a genetic problem of fat metabolism.
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Meta-Analysis of BRCA1 and BRCA2 Penetrance - 0 views

www.ncbi.nlm.nih.gov/...PMC2267287 BRCA 1 BRCA 2 SNPs single nucleotide polymorphisms cancer breast cancer ovarian cancer
shared by Nathan Goodyear on 18 Sep 17 - No Cached
  • The resulting cumulative risks by age 70 years are as follows: breast cancer risk of 55% (95% CI, 50% to 59%) for BRCA1 and 47% (95% CI, 42% to 51%) for BRCA2 mutation carriers;and ovarian cancer risk of 39% (95% CI,34% to 45%) for BRCA1 and 17% (95% CI,13% to 21%) for BRCA2 mutation carriers
  • Nathan Goodyear on 18 Sep 17
     
    good meta-analysis and discussion of the heterogenous penetrance of BRCA1 and BRCA2.  This study found lower penetrance compared to previous studies i.e. 55% breast cancer risk and 39% ovarian cancer risk in BRCA1
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The rs5934505 single nucleotide polymorphism (SNP) is associated with low testosterone ... - 0 views

www.ncbi.nlm.nih.gov/...26602056 epigenetics low T low Testosterone Testosterone SNPs
shared by Nathan Goodyear on 19 Sep 17 - No Cached
  • Nathan Goodyear on 19 Sep 17
     
    Four SNPs, rs12150660, rs727428, rs5934505, and rs10822184 associated with late-onset hypogonadism (low T) and obesity in men of European descent.  In Chinese populations, rs5934505 was associated with increased risk of low Total Testosterone and calculated free Testosterone.  OR was 2.01 for low TT and 2.14 for low calculated free Testosterone.
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The Single Nucleotide Polymorphism Gly482Ser in the PGC-1α Gene Impairs Exerc... - 0 views

journals.plos.org/...article epigenetics exercise training muscle SNPs PGC-1alpha
shared by Nathan Goodyear on 30 Nov 17 - No Cached
  • Oxidative slow-twitch type I fibres (henceforth briefly called ‘slow fibres’) contain MHC-Iβ. They use oxidative phosphorylation (OXPHOS) to generate ATP and are thus highly fatigue resistant and preferentially activated during endurance exercise. Slow fibres comprise high amounts of mitochondria, myoglobin and lipid droplets, and are well supplied by capillaries
  • there are three types of fast-twitch fibres (types IIA, IID/X, IIB, with the corresponding MHC isoforms IIa, IId/x, IIb) which are all used for rapid high-force generation. Oxidative-glycolytic fast-twitch type IIA fibres have intermediate amounts of mitochondria, lipid droplets and capillaries, and are intermediately resistant to fatigue (as compared to type I and types IIB and IID/X). Glycolytic fast-twitch type IID/X fibres are poor in mitochondria, lipids and capillaries and more susceptible to fatique than type IIA. Glycolytic fast-twitch type IIB fibres have the lowest amounts of mitochondria, lipid droplets and capillaries, but generate the highest contraction velocities
  • Several studies have shown that PGC-1α is upregulated after endurance training
  • ...3 more annotations...
  • upregulation of PGC-1α expression enhances and/or maintains mitochondrial biogenesis, eventually leading to an increased mitochondrial content of the muscle fibres.
  • PGC-1α also plays an important role in the pathogenesis of insulin resistance and T2D
  • carriers of the Gly482Ser SNP have a reduced cardiorespiratory fitness and a higher risk for metabolic syndrome and T2D
  • Nathan Goodyear on 30 Nov 17
     
    Those that carry the risk SNP for Gly482Ser for the PGC-1alpha gene dont' transform type II to type I and thus decrease the effectiveness of aeorbic exercise training, decreased oxidative phosphorylation, decreased lipid oxidation, increased lipid accumulaiton in muscle, and increased risk of IR, obesity, and diabetes.
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